Michael Sittinger Professor Head of Tissue Engineering Laboratory Charite - University Medicine Germany phone +4930450513198 fax +4930450513943 email michael.sittinger@tissue-engineering.de homepage http://www.charite.de/te/ Zip Code 10117 City Berlin

Research interests, comments

Mesenchymal Stem and Progenitor Cells (MSC), Bone, Cartilage, Cardiac and Vascular Tissue engineering, Biomaterials, Chemokines, Joint Diseases, Arthritis, In Vitro Models

Publications (Source: PubMed Database for Michael Sittinger)

Hutmacher DW, Ng KW, Kaps C, Sittinger M, Kläring S
Elastic cartilage engineering using novel scaffold architectures in combination with a biomimetic cell carrier.
Biomaterials 2003-11; 24(24):4445-58

Endres M, Hutmacher DW, Salgado AJ, Kaps C, Ringe J, Reis RL, Sittinger M, Brandwood A, Schantz JT
Osteogenic induction of human bone marrow-derived mesenchymal progenitor cells in novel synthetic polymer-hydrogel matrices.
Tissue Eng 2003-08; 9(4):689-702

Schmelzeisen R, Schimming R, Sittinger M
Making bone: implant insertion into tissue-engineered bone for maxillary sinus floor augmentation-a preliminary report.
J Craniomaxillofac Surg 2003-02; 31(1):34-9

Erggelet C, Sittinger M, Lahm A
The arthroscopic implantation of autologous chondrocytes for the treatment of full-thickness cartilage defects of the knee joint.
Arthroscopy 2003-01; 19(1):108-10

Hutmacher DW, Sittinger M
Periosteal cells in bone tissue engineering.
Tissue Eng 2003; 9 Suppl 1:S45-64

Groger A, Klaring S, Merten HA, Holste J, Kaps C, Sittinger M
Tissue engineering of bone for mandibular augmentation in immunocompetent minipigs: preliminary study.
Scand J Plast Reconstr Surg Hand Surg 2003; 37(3):129-33

Barnewitz D, Evers A, Zimmermann J, Wilke I, Kaps C, Sittinger M
[Tissue engineering: new treatment of cartilage alterations in degenerative joint diseases in horses--preliminary results of a long term study]
Berl Munch Tierarztl Wochenschr 2003; 116(3-4):157-61

Schmelzeisen R, Schimming R, Sittinger M
Soft tissue and hard tissue engineering in oral and maxillofacial surgery.
Ann R Australas Coll Dent Surg 2002-10; 16:50-3

Ringe J, Kaps C, Burmester GR, Sittinger M
Stem cells for regenerative medicine: advances in the engineering of tissues and organs.
Naturwissenschaften 2002-08; 89(8):338-51

Risbud MV, Sittinger M
Tissue engineering: advances in in vitro cartilage generation.
Trends Biotechnol 2002-08; 20(8):351-6

Kaps C, Loch A, Haisch A, Smolian H, Burmester GR, Häupl T, Sittinger M
Human platelet supernatant promotes proliferation but not differentiation of articular chondrocytes.
Med Biol Eng Comput 2002-07; 40(4):485-90

Haisch A, Klaering S, Groeger A, Gebert C, Sittinger M
A tissue-engineering model for the manufacture of auricular-shaped cartilage implants.
Eur Arch Otorhinolaryngol 2002-07; 259(6):316-21

Ringe J, Kaps C, Schmitt B, Büscher K, Bartel J, Smolian H, Schultz O, Burmester GR, Häupl T, Sittinger M
Porcine mesenchymal stem cells Induction of distinct mesenchymal cell lineages.
Cell Tissue Res 2002-03; 307(3):321-7

Ziegelaar BW, Aigner J, Staudenmaier R, Lempart K, Mack B, Happ T, Sittinger M, Endres M, Naumann A, Kastenbauer E, Rotter N
The characterisation of human respiratory epithelial cells cultured on resorbable scaffolds: first steps towards a tissue engineered tracheal replacement.
Biomaterials 2002-03; 23(6):1425-38

Kaps C, Bramlage C, Smolian H, Haisch A, Ungethüm U, Burmester GR, Sittinger M, Gross G, Häupl T
Bone morphogenetic proteins promote cartilage differentiation and protect engineered artificial cartilage from fibroblast invasion and destruction.
Arthritis Rheum 2002-01; 46(1):149-62

Smolian H, Aurer A, Sittinger M, Zacher J, Bernimoulin JP, Burmester GR, Kolkenbrock H
Secretion of gelatinases and activation of gelatinase A (MMP-2) by human rheumatoid synovial fibroblasts.
Biol Chem 2001-10; 382(10):1491-9

Risbud M, Endres M, Ringe J, Bhonde R, Sittinger M
Biocompatible hydrogel supports the growth of respiratory epithelial cells: possibilities in tracheal tissue engineering.
J Biomed Mater Res 2001-07; 56(1):120-7

Smolian H, Thiele S, Kolkenbrock H, Zacher J, Aicher W, Schultz O, Burmester GR, Sittinger M
[Establishment of an in vitro model for rheumatoid arthritis as test system for therapeutical substances]
ALTEX 2001; 18(4):265-80

Luebke C, Sittinger M, Burmester GR, Paulitschke M
Cryopreservation of artificial cartilage: viability and functional examination after thawing.
Cells Tissues Organs 2001; 169(4):368-76

Risbud M, Ringe J, Bhonde R, Sittinger M
In vitro expression of cartilage-specific markers by chondrocytes on a biocompatible hydrogel: implications for engineering cartilage tissue.
Cell Transplant 2001; 10(8):755-63

Haisch A, Loch A, David J, Pruss A, Hansen R, Sittinger M
Preparation of a pure autologous biodegradable fibrin matrix for tissue engineering.
Med Biol Eng Comput 2000-11; 38(6):686-9

Perka C, Sittinger M, Schultz O, Spitzer RS, Schlenzka D, Burmester GR
Tissue engineered cartilage repair using cryopreserved and noncryopreserved chondrocytes.
Clin Orthop 2000-09; (378):245-54

Haisch A, Groeger A, Radke C, Ebmeyer J, Sudhoff H, Grasnick G, Jahnke V, Burmester GR, Sittinger M
Macroencapsulation of human cartilage implants: pilot study with polyelectrolyte complex membrane encapsulation.
Biomaterials 2000-08; 21(15):1561-6

Perka C, Schultz O, Spitzer RS, Lindenhayn K, Burmester GR, Sittinger M
Segmental bone repair by tissue-engineered periosteal cell transplants with bioresorbable fleece and fibrin scaffolds in rabbits.
Biomaterials 2000-06; 21(11):1145-53

Perka C, Spitzer RS, Lindenhayn K, Sittinger M, Schultz O
Matrix-mixed culture: new methodology for chondrocyte culture and preparation of cartilage transplants.
J Biomed Mater Res 2000-03-5; 49(3):305-11

Haisch A, Groeger A, Radke C, Ebmeyer J, Sudhoff H, Grasnick G, Jahnke V, Burmester GR, Sittinger M
[Protection of autogenous cartilage transplants from resorption using membrane encapsulation]
HNO 2000-02; 48(2):119-24

Perka C, Schultz O, Sittinger M, Zippel H
[Chondrocyte transplantation in PGLA/polydioxanone fleece]
Orthopade 2000-02; 29(2):112-9

Duda GN, Haisch A, Endres M, Gebert C, Schroeder D, Hoffmann JE, Sittinger M
Mechanical quality of tissue engineered cartilage: results after 6 and 12 weeks in vivo.
J Biomed Mater Res 2000; 53(6):673-7

Schultz O, Sittinger M, Haeupl T, Burmester GR
Emerging strategies of bone and joint repair.
Arthritis Res 2000; 2(6):433-6

Perka C, Lindenhayn K, Heilmann HH, Sittinger M, Muschik M
[Experimental studies of mechanically-induced articular cartilage defects following implantation of allogeneic embryonal chondrocytes in a collagen-fibrin gel in chickens]
Z Orthop Ihre Grenzgeb 2000; 134(6):562-72

Kreklau B, Sittinger M, Mensing MB, Voigt C, Berger G, Burmester GR, Rahmanzadeh R, Gross U
Tissue engineering of biphasic joint cartilage transplants.
Biomaterials 1999-09; 20(18):1743-9

Dunkern TR, Paulitschke M, Meyer R, BĂĽttemeyer R, Hetzer R, Burmester G, Sittinger M
A novel perfusion system for the endothelialisation of PTFE grafts under defined flow.
Eur J Vasc Endovasc Surg 1999-08; 18(2):105-10

Sittinger M, Perka C, Schultz O, Häupl T, Burmester GR
Joint cartilage regeneration by tissue engineering.
Z Rheumatol 1999-06; 58(3):130-5

Lindenhayn K, Perka C, Spitzer R, Heilmann H, Pommerening K, Mennicke J, Sittinger M
Retention of hyaluronic acid in alginate beads: aspects for in vitro cartilage engineering.
J Biomed Mater Res 1999-02; 44(2):149-55

Rotter N, Aigner J, Naumann A, Planck H, Hammer C, Burmester G, Sittinger M
Cartilage reconstruction in head and neck surgery: comparison of resorbable polymer scaffolds for tissue engineering of human septal cartilage.
J Biomed Mater Res 1998-12-5; 42(3):347-56

Minuth WW, Sittinger M, Kloth S
Tissue engineering: generation of differentiated artificial tissues for biomedical applications.
Cell Tissue Res 1998-01; 291(1):1-11

Schultz O, Keyszer G, Zacher J, Sittinger M, Burmester GR
Development of in vitro model systems for destructive joint diseases: novel strategies for establishing inflammatory pannus.
Arthritis Rheum 1997-08; 40(8):1420-8

Rotter N, Sittinger M, Hammer C, Buji­a J, Kastenbauer E
[Transplantation of in vitro cultured cartilage materials: characterization of matrix synthesis]
Laryngorhinootologie 1997-04; 76(4):241-7

Sittinger M, Braeunling J, Kastenbauer E, Hammer C, Burmester G, Buji­a J
[Proliferative potential of nasal septum chondrocytes for in vitro culture of cartilage transplants]
Laryngorhinootologie 1997-02; 76(2):96-100

Sittinger M, Schultz O, Keyszer G, Minuth WW, Burmester GR
Artificial tissues in perfusion culture.
Int J Artif Organs 1997-01; 20(1):57-62

Haisch A, Schultz O, Perka C, Jahnke V, Burmester GR, Sittinger M
[Tissue engineering of human cartilage tissue for reconstructive surgery using biocompatible resorbable fibrin gel and polymer carriers]
HNO 1996-11; 44(11):624-9

Bujia J, Sittinger M, Sudhoff H, Fisseler-Eckhoff A, Burmester GR, Kastenbauer E, Hammer C
Monoclonal antibodies against human chondrocytes.
In Vitro Cell Dev Biol Anim 1996-06; 32(6):366-71

Sittinger M, Jerez R, Burmester GR, Krafft T, Spitzer W
Antibodies to collagens in sera from patients receiving bovine cartilage graft.
Ann Rheum Dis 1996-05; 55(5):333-4

Sittinger M, Lukanoff B, Burmester GR, Dautzenberg H
Encapsulation of artificial tissues in polyelectrolyte complexes: preliminary studies.
Biomaterials 1996-05; 17(10):1049-51

Minuth WW, Kloth S, Aigner J, Sittinger M, Roeckl W
Approach to an organo-typical environment for cultured cells and tissues.
Biotechniques 1996-03; 20(3):498-501

Gruber R, Sittinger M, Buji­a J
[In vitro cultivation of human chondrocytes using autologous human serum supplemented culture medium: minimizing possible risk of infection with pathogens of prion diseases]
Laryngorhinootologie 1996-02; 75(2):105-8

Sittinger M, Bujia J, Rotter N, Reitzel D, Minuth WW, Burmester GR
Tissue engineering and autologous transplant formation: practical approaches with resorbable biomaterials and new cell culture techniques.
Biomaterials 1996-02; 17(3):237-42

Sittinger M, Reitzel D, Dauner M, Hierlemann H, Hammer C, Kastenbauer E, Planck H, Burmester GR, Bujia J
Resorbable polyesters in cartilage engineering: affinity and biocompatibility of polymer fiber structures to chondrocytes.
J Biomed Mater Res 1996; 33(2):57-63

Perka C, Schultz O, Lindenhayn K, Spitzer RS, Muschik M, Sittinger M, Burmester GR
Joint cartilage repair with transplantation of embryonic chondrocytes embedded in collagen-fibrin matrices.
Clin Exp Rheumatol 1996; 18(1):13-22

Sittinger M
[Tissue engineering: artificial tissue replacement containing vital components]
Laryngorhinootologie 1995-11; 74(11):695-9

BujĂ­a J, Rotter N, Minuth W, Burmester G, Hammer C, Sittinger M
[Cultivation of human cartilage tissue in a 3-dimensional perfusion culture chamber: characterization of collagen synthesis]
Laryngorhinootologie 1995-09; 74(9):559-63

Holly A, Sittinger M, Buji­a J
[Immunohistochemical detection of c-myc proto-oncogene products in middle ear cholesteatoma]
Laryngorhinootologie 1995-06; 74(6):348-51

Buji­a J, Reitzel M, Sittinger
[In vitro cultivation of cartilage tissue for reconstructive surgery: effect of L(+)-lactate and glycolate on cultivated human chondrocytes]
Laryngorhinootologie 1995-03; 74(3):183-7

Bujia J, Sittinger M, Minuth WW, Hammer C, Burmester G, Kastenbauer E
Engineering of cartilage tissue using bioresorbable polymer fleeces and perfusion culture.
Acta Otolaryngol 1995-03; 115(2):307-10

Holly A, Sittinger M, Bujia J
Immunohistochemical demonstration of c-myc oncogene product in middle ear cholesteatoma.
Eur Arch Otorhinolaryngol 1995; 252(6):366-9

BujĂ­a J, Sittinger M, Hammer C, Burmester G
[Culture of human cartilage tissue using a perfusion chamber]
Laryngorhinootologie 1994-11; 73(11):577-80

Sittinger M, Bujia J, Burmester GR
Inexpensive computer analysis of cell and tissue stainings.
In Vitro Cell Dev Biol Anim 1994-09; 30A(9):559-61

BujĂ­a J, Sittinger M, Wilmes E, Hammer C
Effect of growth factors on cell proliferation by human nasal septal chondrocytes cultured in monolayer.
Acta Otolaryngol 1994-09; 114(5):539-43

Sittinger M, Bujia J, Minuth WW, Hammer C, Burmester GR
Engineering of cartilage tissue using bioresorbable polymer carriers in perfusion culture.
Biomaterials 1994-05; 15(6):451-6

Bujia J, Alsalameh S, Naumann A, Wilmes E, Sittinger M, Burmester GR
Humoral immune response against minor collagens type IX and XI in patients with cartilage graft resorption after reconstructive surgery.
Ann Rheum Dis 1994-04; 53(4):229-34

Buji­a J, Alsalameh S, Jerez R, Sittinger M, Wilmes E, Burmester G
Antibodies to the minor cartilage collagen type IX in otosclerosis.
Am J Otol 1994-03; 15(2):222-4

BujĂ­a J, Alsalameh S, Sittinger M, Hammer C, Wilmes E, Burmester G
Antigen presenting cell function of class II positive human nasal chondrocytes.
Acta Otolaryngol 1994-01; 114(1):75-9

Buji­a J, Sittinger M, Arnold B, Wilmes E, Hammer C, Burmester G
[Cartilage-specific autoimmunity in otosclerosis]
HNO 1993-11; 41(11):507-11

Buji­a J, Sittinger M, Pitzke P, Wilmes E, Hammer C
Synthesis of human cartilage using organotypic cell culture.
ORL J Otorhinolaryngol Relat Spec 1993; 55(6):347-51