!!Prospects on liver tissue engineering
2010-04-30, New review on technology
Treatmeant of patients with liver failure is an enourmous unmet clinical need. There is an urgend need to develop liver tissue engineering to maintain or improve liver function. Liver tissue engineering is an innovative way to construct implantable liver tissue with the potential to alleviate the shortage of organ donors. The concept of liver tissue engineering is very challenging due to the complexity of liver tissue. An new review by Ming-Hua Zheng, et al., published in Cytotherapy, discusses the current progress of the field liver tissue engineering, including the major aspects cell sources, scaffolds and vascularization. The identification of a reliable cell source is the key issue and the review includes hepatic, non-hepatic stem cells, immortalized cell lines, embryonic stem cells or umibilical cord blood stem cells. The concepts for scaffolds lists combinations of materials, modification of biomaterial structure and surface to provide the optimal microenvironment for cells. For vascularization, approaches for in vivo angiogenesis (growth type) and in vitro generation (production type) are mentioned.
Editor: Michael Sittinger
Quelle: Cytotherapy. 2010 May;12(3):349-60
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Lung tissue engineering
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Prospects on liver tissue engineering
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